Methotrexate is the analog of folic acid, which in turn is the quick-dissolving form of vitamin B9. Folic acid plays a big role in process of cell division, when the information from DNA is doubled and further divided between daughter cells.
The main active form of folic acid is tetrahydrofolic acid, formed by the enzyme dihydrofolate reductase. Tetrahydrofolic acid participates in process of doubling DNA in all the phases of fast cell division, including cancer tumors, developed from epithelial tissue in different organs.
Methotrexate pharmacological effect is to inhibit (deactivate) the action of dihydrofolate reductase enzyme and thereby hinder the formation of tetrahydrofolic acid.
By hindering the formation of tetrahydrofolic acid, Methotrexate suppresses the synthesis of DNA in rapidly growing malignant cells. Thus, it should be noted that Methotrexate violates the splitting cells process mostly in malignant neoplasms without causing irreversible change in process of cells division in healthy tissues.
Modern clinical practice actively uses Methotrexate medication for the treatment of autoimmune diseases and plays a significant role in therapeutic treatment of neoplastic diseases.
Anti-tumor Methotrexate medication is indicated for treatment of:
- rheumatoid arthritis in adults
- juvenile rheumatoid arthritis in children*
- gestational choriocarcinoma
- chorioadenoma destruens
- hydatidiform mole
- acute lymphoblastic leukemia
- breast cancer
- epidermoid cancer of the neck and head
- mycosis fungoides
- lung cancer
- advanced stage non-Hodgkin’s lymphoma.
*In treatment of rheumatoid arthritis in adults and juvenile rheumatoid arthritis in children, Methotrexate medication is appointed in cases when maximum doses of NSAIDs cannot give you good therapeutic effect.
Methotrexate drug can be used for monotherapy of neoplastic diseases or being combined with other anti-tumor and chemotherapeutic drugs.
Pharmaceutical form of Methotrexate medication
- Methotrexate medication is produced in pills for oral intake – in dosage of 2,5mg.
- One pill of Methotrexate 2,5mg contains 2,5mg of the active substance Methotrexate sodium.
- Additional inactive ingredients in Methotrexate 2,5mg tablets are: lactose; pregelatinized starch; magnesium stearate; sodium starch glycolate; sodium hydroxide.
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